Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 9/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2448358 | 0.90 | TRPA1 (0.38) | TRPA1ADORA2BADORA1ADORA3MAOB | |
| SCHEMBL2444547 | 0.87 | TRPA1 (0.38) | TRPA1ADORA2BADORA1ADORA3MAOB | |
| SCHEMBL2447649 | 0.82 | TRPA1 (0.40) | TRPA1MAOBTRPM8TRPV1MAOA | |
| SCHEMBL2446463 | 0.81 | TRPA1 (0.38) | TRPA1ADORA2BADORA1ADORA3TRPM8 | |
| SCHEMBL2446470 | 0.81 | TRPA1 (0.38) | TRPA1ADORA2BADORA1ADORA3TRPM8 | |
| SCHEMBL2448248 | 0.80 | ACP1 (0.36) | TRPA1ADORA2BADORA1ADORA3MAOB | |
| SCHEMBL2444312 | 0.79 | TRPA1 (0.35) | TRPA1ADORA2BADORA1ADORA3MAOB | |
| Hydrochloric Acid SCHEMBL2448234 | 0.79 | ACP1 (0.35) | TRPA1ADORA2BADORA1ADORA3MAOB | |
| SCHEMBL2442250 | 0.78 | TRPA1 (0.35) | TRPA1ADORA2BADORA1ADORA3MAOB | |
| SCHEMBL16789219 | 0.78 | TRPA1 (0.37) | TRPA1ADORA2BADORA1ADORA3TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680098-B2 | Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-03-25 | — | — | US | disclosed |