Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | CASP3 | P42574 | 2/20 | 0.69 |
| ▸ | APAF1 | O14727 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.69 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15627434 | 0.87 | MEN1 (0.70) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL3851940 | 0.82 | MEN1 (0.77) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL2580937 | 0.82 | KMT2A (1.00) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL31259596 | 0.81 | CHRM5 (0.49) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL31430163 | 0.81 | MEN1 (0.51) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL31259672 | 0.80 | MEN1 (0.48) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL31259599 | 0.79 | KDM4E (0.60) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL31259624 | 0.79 | KDM4E (0.49) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL14938439 | 0.76 | MEN1 (0.71) | MEN1KMT2ACASP3APAF1GAA | |
| SCHEMBL15627197 | 0.76 | KDM4E (0.48) | MEN1KMT2ACASP3APAF1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897938-B1 | FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-2897938-B1 | FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9133126-B2 | Fluoroalkyl dibenzoazepinone compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133126-B2 | Fluoroalkyl dibenzoazepinone compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| US-20150218104-A1 | FLUOROALKYL DIBENZOAZEPINONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2015-08-06 | — | — | US | disclosed |
| US-20150218104-A1 | FLUOROALKYL DIBENZOAZEPINONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2015-08-06 | — | — | US | disclosed |
| EP-2897938-A1 | FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2015-07-29 | — | — | EP | disclosed |
| WO-2014047370-A1 | FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-03-27 | — | — | WO | disclosed |
| WO-2014047370-A1 | FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218104-A1 | FLUOROALKYL DIBENZOAZEPINONE COMPOUNDS | DNER, NOTCH3, BCR | MEN1 2575/4885KMT2A 1205/4885CASP3 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.