Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 16/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15194020 | 0.89 | MAP3K14 (0.51) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL12539137 | 0.88 | MAP3K14 (0.63) | MAP3K14PIK3CDPIK3R1PRKD1 | |
| SCHEMBL15193034 | 0.88 | MAP3K14 (0.50) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL12693222 | 0.85 | GABRG2 (0.55) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL12689305 | 0.83 | MAP3K14 (0.46) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL19594747 | 0.82 | PIK3CA (0.55) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL12539624 | 0.82 | MAP3K14 (0.46) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1485015 | 0.80 | MAP3K14 (0.44) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL1485090 | 0.79 | PIK3CA (0.54) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1484994 | 0.79 | MAP3K14 (0.55) | MAP3K14PIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2845592-A1 | Benzoxazepin PI3K inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2015-03-11 | — | — | EP | disclosed |
| EP-2711368-A1 | Benzoxazepin PI3K inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |