⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462821 | 1.00 | — | — | |
| SCHEMBL6322553 | 0.98 | — | — | |
| SCHEMBL19181540 | 0.91 | CA1 (0.37) | — | |
| SCHEMBL3506384 | 0.90 | — | — | |
| SCHEMBL25246055 | 0.88 | CA1 (0.39) | — | |
| SCHEMBL6234011 | 0.85 | — | — | |
| SCHEMBL25244924 | 0.83 | CA1 (0.39) | — | |
| SCHEMBL25356176 | 0.82 | ALDH1A1 (0.32) | — | |
| SCHEMBL25356175 | 0.80 | — | — | |
| SCHEMBL158642 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002251-A1 | HUMAN TLR8-SELECTIVE AGONISTS | UNIVERSITY OF KANSAS (US) | 2022-01-06 | — | — | US | disclosed |
| US-11130736-B2 | Human TLR8-selective agonists | UNIVERSITY OF KANSAS (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200377497-A1 | NONTOXIC COMPOUNDS FOR THE TREATMENT AND PREVENTION OF HERPESVIRUS INFECTIONS | THE PENN STATE RESEARCH FOUNDATION | 2020-12-03 | — | — | US | disclosed |
| EP-3337481-B1 | QUINOLINE-2-AMINE DERIVATIVES AS HUMAN TLR8-SELECTIVE AGONISTS FOR INCREASING IMMUNE RESPONSE | UNIV KANSAS (US) | 2020-11-11 | — | — | EP | disclosed |
| US-10781203-B2 | Nontoxic compounds for the treatment and prevention of herpesvirus infections | THE PENN STATE RESEARCH FOUNDATION (US) | 2020-09-22 | — | — | US | disclosed |
| US-20190241553-A1 | Nontoxic compounds for the treatment and prevention of herpesvirus infections | THE PENN STATE RESEARCH FOUNDATION (US) | 2019-08-08 | — | — | US | disclosed |
| US-20180258045-A1 | HUMAN TLR8-SELECTIVE AGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-09-13 | — | — | US | disclosed |
| EP-3337481-A1 | HUMAN TLR8-SELECTIVE AGONISTS | The University of Kansas (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2018017853-A1 | NONTOXIC COMPOUNDS FOR THE TREATMENT AND PREVENTION OF HERPESVIRUS INFECTIONS | THE PENN STATE RESEARCH FOUNDATION (US) | 2018-01-25 | — | — | WO | disclosed |
| US-9676818-B2 | Toll-like receptor 2-agonistic lipopeptides, and method of making the same | UNIVERSITY OF KANSAS (US) | 2017-06-13 | — | — | US | disclosed |
| WO-2017034986-A1 | HUMAN TLR8-SELECTIVE AGONISTS | UNIVERSITY OF KANSAS (US) | 2017-03-02 | — | — | WO | disclosed |
| US-20150337009-A1 | TOLL-LIKE RECEPTOR 2-AGONISTIC LIPOPEPTIDES, AND METHOD OF MAKING THE SAME | UNIVERSITY OF KANSAS | 2015-11-26 | — | — | US | disclosed |
| WO-2014113634-A1 | TOLL-LIKE RECEPTOR 2-AGONISTIC LIPOPEPTIDES, AND METHOD OF MAKING THE SAME | UNIVERSITY OF KANSAS (US) | 2014-07-24 | — | — | WO | disclosed |
| US-20140018566-A1 | PALLADIUM(II)-CATALYZED SELECTIVE FLUORINATION OF BENZOIC ACIDS AND DERIVATIVES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-01-16 | — | — | US | disclosed |
| WO-2012088402-A1 | SYNTHESIS OF CONOLIDINE AND DISCOVERY OF A POTENT NON-OPIOID ANALGESIC FOR PAIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-06-28 | — | — | WO | disclosed |
| US-20120059179-A1 | PALLADIUM-CATALYZED ORTHO-FLUORINATION | The Scripps Research Insitiute (US) | 2012-03-08 | — | — | US | disclosed |
| EP-2414317-A2 | PALLADIUM-CATALYZED ORTHO-FLUORINATION | The Scripps Research Institute (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115098-A2 | PALLADIUM-CATALYZED ORTHO-FLUORINATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-10-07 | — | — | WO | disclosed |