Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12292630 | 0.85 | HTT (0.60) | HTTFOLH1SIRT2TGM2SIRT1 | |
| SCHEMBL12292620 | 0.83 | HTT (0.55) | HTTFOLH1SIRT2TGM2SIRT1 | |
| SCHEMBL13322688 | 0.80 | HTT (0.59) | HTTFOLH1SIRT2TGM2SIRT1 | |
| SCHEMBL12292637 | 0.80 | MAPT (0.48) | MAPTHTTFOLH1SIRT2TGM2 | |
| SCHEMBL15502104 | 0.77 | SYK (0.49) | MAPTHTTSIRT2TGM2KLK7 | |
| SCHEMBL8838459 | 0.76 | MAPT (0.67) | MAPTHTTFOLH1KLK7KLK5 | |
| SCHEMBL30915257 | 0.76 | MAPT (0.67) | MAPTHTTFOLH1KLK7KLK5 | |
| SCHEMBL29401232 | 0.76 | MAPT (0.67) | MAPTHTTFOLH1KLK7KLK5 | |
| SCHEMBL2512643 | 0.75 | MAPT (0.63) | MAPTHTTFOLH1TGM2KLK7 | |
| SCHEMBL21789935 | 0.75 | MAPT (0.63) | MAPTHTTFOLH1TGM2KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789553-B1 | OLIGONUCLEOTIDES COMPRISING A NON-PHOSPHATE BACKBONE LINKAGE | ALNYLAM PHARMACEUTICALS INC (US) | 2014-03-26 | — | — | EP | disclosed |