Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1054521 | 0.81 | POLB (0.53) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL14222811 | 0.79 | POLB (0.43) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL6564650 | 0.72 | POLB (0.50) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL6564657 | 0.72 | POLB (0.50) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL6564653 | 0.72 | POLB (0.50) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL29433500 | 0.71 | POLB (0.62) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL6564351 | 0.71 | POLB (0.62) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL27623883 | 0.70 | POLB (0.56) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL16891501 | 0.68 | POLB (0.58) | POLBHCAR2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL27522590 | 0.68 | CYP2C19 (0.56) | POLBHCAR2KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102229-B1 | PYRROLYDINE DERIVATIVES AS IAP INHIBITORS | NOVARTIS AG (CH) | 2014-03-26 | — | — | EP | disclosed |