Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1054521 | 0.83 | POLB (0.53) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL5094634 | 0.81 | KDM4E (0.67) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL29419378 | 0.79 | POLB (0.62) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL29433500 | 0.79 | POLB (0.62) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL6118965 | 0.79 | POLB (0.62) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL6564351 | 0.79 | POLB (0.62) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL31585319 | 0.79 | POLB (0.61) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL28019454 | 0.78 | POLB (0.51) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL9672142 | 0.78 | POLB (0.60) | POLBHCAR2KDM4EHTTALOX15 | |
| Bromide SCHEMBL6117799 | 0.78 | POLB (0.60) | POLBHCAR2KDM4EHTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100349895-C | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC (JP) | 2007-11-21 | — | — | CN | disclosed |
| CN-1759117-A | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC (JP) | 2006-04-12 | — | — | CN | disclosed |