Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | LSS | P48449 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28582005 | 0.98 | CYP2A6 (0.56) | CYP2A6HRH3LSSLOXL2ALDH1A1 | |
| SCHEMBL10924184 | 0.94 | LSS (0.57) | CYP2A6HRH3LSSLOXL2ALDH1A1 | |
| SCHEMBL10925683 | 0.89 | SNCA (0.50) | CYP2A6HRH3LSSLOXL2ALDH1A1 | |
| SCHEMBL10925686 | 0.89 | SNCA (0.50) | CYP2A6HRH3LSSLOXL2ALDH1A1 | |
| SCHEMBL10928213 | 0.86 | MAOB (0.62) | HRH3SLC6A4 | |
| SCHEMBL6246127 | 0.83 | CYP2A6 (0.54) | CYP2A6HRH3LSSLOXL2ALDH1A1 | |
| SCHEMBL12977907 | 0.83 | CYP2A6 (0.54) | CYP2A6HRH3LSSLOXL2ALDH1A1 | |
| SCHEMBL23374744 | 0.81 | CYP2A6 (0.57) | CYP2A6HRH3LOXL2ALDH1A1TSHR | |
| SCHEMBL659509 | 0.80 | HRH3 (0.82) | HRH3ALDH1A1TSHRTAAR1POLB | |
| SCHEMBL129128 | 0.79 | CYP2A6 (0.50) | CYP2A6HRH3LSSLOXL2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001973-B2 | Catalyst and process for preparing low-viscosity and color-reduced polyisocyanates containing isocyanurate groups | DEGUSSA AG (DE) | 2006-02-21 | — | — | US | claimed |
| US-20030187178-A1 | Catalyst and process for preparing low-viscosity and color-reduced polyisocyanates containing isocyanurate groups | DEGUSSA AG (DE) | 2003-10-02 | — | — | US | claimed |
| US-6613863-B2 | Benzyltrialkylammonium carboxylate isocyanate trimerization catalysts | DEGUSSA AG (DE) | 2003-09-02 | — | — | US | claimed |
| US-20020120089-A1 | Catalyst and process for preparing low-viscosity and color-reduced polyisocyanates containing isocyanurate groups | DEGUSSA AG (DE) | 2002-08-29 | — | — | US | claimed |
| EP-3568390-B1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST (US) | 2024-03-06 | — | — | EP | disclosed |
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-11-07 | — | — | US | disclosed |
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-11-07 | — | — | US | disclosed |
| CN-116390908-A | Antiviral treatment | 生态合成股份有限公司 | 2023-07-04 | — | — | CN | disclosed |
| US-20230116770-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2023-04-13 | — | — | US | disclosed |
| US-20230015767-A1 | PHOTOSENSITIVE COLORING COMPOSITION, CURED SUBSTANCE, COLOR FILTER, SOLID-STATE IMAGING ELEMENT, IMAGE DISPLAY DEVICE, AND ASYMMETRIC DIKETOPYRROLOPYRROLE COMPOUND | FUJIFILM CORPORATION (JP) | 2023-01-19 | — | — | US | disclosed |
| US-11452717-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-09-27 | — | — | US | disclosed |
| US-20210161873-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2021-06-03 | — | — | US | disclosed |
| US-6262292-B1 | FORMING CYANAOBENZALDEHYDE BY OXIDATION OF CYANOBENZYLAMINE | SHOWA DENKO K.K. (JP) | 2001-07-17 | — | — | US | disclosed |
| EP-1083165-A1 | PROCESSES FOR PRODUCING CYANOPHENYL DERIVATIVES | Showa Denko Kabushiki Kaisha (JP) | 2001-03-14 | — | — | EP | disclosed |
| EP-0370693-B1 | Novel onium salts and the use thereof as photoinitiators | EASTMAN KODAK CO (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5141969-A | Onium salts and the use thereof as photoinitiators | EASTMAN KODAK COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-5055376-A | Curable compositions containing onium salt photoinitiators which have a chromophore linked to the onium salt moiety through the 3-position and method of use | EASTMAN KODAK COMPANY (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0370693-A2 | Novel onium salts and the use thereof as photoinitiators | EASTMAN KODAK COMPANY (US) | 1990-05-30 | — | — | EP | disclosed |
| US-4154928-A | Substituted isoxazolo compounds | SANDOZ, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4113727-A | Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones | SANDOZ, INC. (US) | 1978-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11452717-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | NAMPT, NAPRT, NNT | CYP2A6 3308/4885HRH3 3547/4885LSS 1851/4885 |
| US-20210161873-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | NAMPT, NAPRT, NNT | CYP2A6 3308/4885HRH3 3547/4885LSS 1851/4885 |
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | NAMPT, NAPRT, NNT | CYP2A6 3308/4885HRH3 3547/4885LSS 1851/4885 |
| US-20230116770-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | NAMPT, NAPRT, NNT | CYP2A6 3308/4885HRH3 3547/4885LSS 1851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.