Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 5/20 | 0.34 |
| ▸ | YEATS4 | O95619 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18432894 | 1.00 | APLNR (0.56) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL17152354 | 1.00 | APLNR (0.56) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL17152593 | 1.00 | APLNR (0.56) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL15627769 | 1.00 | APLNR (0.56) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL17152282 | 0.91 | APLNR (0.48) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL15627757 | 0.91 | APLNR (0.48) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL18433166 | 0.91 | APLNR (0.48) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL17152471 | 0.91 | APLNR (0.48) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL17152296 | 0.91 | APLNR (0.68) | APLNRALDH1A1HPGDNPC1LMNA | |
| SCHEMBL15627839 | 0.91 | APLNR (0.68) | APLNRALDH1A1HPGDNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| WO-2014044738-A1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES AS APJ RECEPTOR MODULATORS | SANOFI (FR) | 2014-03-27 | — | — | WO | disclosed |