Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.63 |
| ▸ | CDK2AP1 | O14519 | 3/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563538 | 0.97 | CHEK1 (0.62) | CHEK1CDK2AP1MAP4K4IKBKBJAK2 | |
| SCHEMBL4991815 | 0.93 | CHEK1 (0.55) | CHEK1CDK2AP1MAP4K4IKBKB | |
| SCHEMBL1563525 | 0.91 | CHEK1 (0.52) | CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL5004723 | 0.91 | CHEK1 (0.53) | CHEK1CDK2AP1 | |
| SCHEMBL4994950 | 0.91 | CHEK1 (0.53) | CHEK1CDK2AP1 | |
| SCHEMBL5001067 | 0.90 | CHEK1 (0.54) | CHEK1CDK2AP1MAP4K4IKBKB | |
| SCHEMBL4994981 | 0.88 | CHEK1 (0.52) | CHEK1CDK2AP1 | |
| SCHEMBL1563673 | 0.87 | GAA (0.48) | CHEK1IKBKB | |
| SCHEMBL5001092 | 0.85 | CHEK1 (0.55) | CHEK1CDK2AP1IKBKB | |
| SCHEMBL1563829 | 0.85 | CHEK1 (0.44) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |