Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1564588 | 0.97 | GAA (0.47) | GAAMAPTGFERCHEK1ALOX15 | |
| SCHEMBL1562835 | 0.87 | CHEK1 (0.63) | CHEK1IKBKB | |
| SCHEMBL1563525 | 0.86 | CHEK1 (0.52) | CHEK1RAB9A | |
| SCHEMBL1563538 | 0.84 | CHEK1 (0.62) | CHEK1IKBKB | |
| SCHEMBL5000965 | 0.83 | CHEK1 (0.50) | GAAMAPTGFERCHEK1ALOX15 | |
| SCHEMBL1770910 | 0.81 | CHEK1 (0.42) | GAAMAPTGFERCHEK1ALDH1A1 | |
| SCHEMBL4991815 | 0.80 | CHEK1 (0.55) | CHEK1IKBKB | |
| SCHEMBL1562877 | 0.79 | CHEK1 (0.46) | CHEK1ALDH1A1HPGDRAB9A | |
| SCHEMBL1564850 | 0.79 | MAPT (0.49) | GAAMAPTGFERCHEK1ALDH1A1 | |
| SCHEMBL5004723 | 0.78 | CHEK1 (0.53) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |