Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 17/20 | 0.54 |
| ▸ | NOTCH3 | Q9UM47 | 13/20 | 0.54 |
| ▸ | RBPJ | Q06330 | 4/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15608298 | 1.00 | NOTCH1 (0.54) | NOTCH1NOTCH3RBPJPBRM1NSD2 | |
| SCHEMBL15608441 | 0.92 | NOTCH1 (0.53) | NOTCH1NOTCH3RBPJNSD2BCHE | |
| SCHEMBL15629461 | 0.92 | NOTCH1 (0.53) | NOTCH1NOTCH3RBPJNSD2BCHE | |
| SCHEMBL17030687 | 0.88 | NOTCH1 (0.42) | NOTCH1NOTCH3RBPJNSD2BCHE | |
| SCHEMBL17030724 | 0.87 | NOTCH1 (0.50) | NOTCH1NOTCH3RBPJNSD2BCHE | |
| SCHEMBL15629496 | 0.87 | NOTCH1 (0.52) | NOTCH1NOTCH3RBPJNSD2BCHE | |
| SCHEMBL15608200 | 0.87 | NOTCH1 (0.52) | NOTCH1NOTCH3RBPJNSD2BCHE | |
| SCHEMBL15623736 | 0.86 | NOTCH1 (0.46) | NOTCH1NOTCH3RBPJNSD2BCHE | |
| SCHEMBL15628179 | 0.86 | NOTCH1 (0.46) | NOTCH1NOTCH3RBPJNSD2BCHE | |
| SCHEMBL17019559 | 0.86 | NOTCH1 (0.47) | NOTCH1NOTCH3RBPJ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897947-B1 | ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-26 | — | — | EP | disclosed |
| US-9427442-B2 | Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-08-30 | — | — | US | disclosed |
| US-9273014-B2 | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-03-01 | — | — | US | disclosed |
| US-9242941-B2 | Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150239851-A1 | ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL-METERS SQUIBB COMPANY (US) | 2015-08-27 | — | — | US | disclosed |
| US-20150231152-A1 | FLUOROALKYL AND FLUOROCYCLOALKYL 1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2015-08-20 | — | — | US | disclosed |
| US-20150166489-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2015-06-18 | — | — | US | disclosed |
| US-8999918-B2 | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-04-07 | — | — | US | disclosed |
| US-20140087992-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2014-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140087992-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF | CNR1, ROR1, RORB | NOTCH1 71/4885NOTCH3 47/4885RBPJ 136/4885 |
| US-20150231152-A1 | FLUOROALKYL AND FLUOROCYCLOALKYL 1,4-BENZODIAZEPINONE COMPOUNDS | CNR1, CNR2, HRH3 | NOTCH1 95/4885NOTCH3 37/4885RBPJ 235/4885 |
| US-20150239851-A1 | ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS | CNR1, CNR2, NR1I3 | NOTCH1 61/4885NOTCH3 34/4885RBPJ 190/4885 |
| US-20150166489-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF | CNR1, ROR1, RORB | NOTCH1 71/4885NOTCH3 47/4885RBPJ 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.