Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.40 |
| ▸ | PPARG | P37231 | 7/20 | 0.40 |
| ▸ | PPARD | Q03181 | 7/20 | 0.40 |
| ▸ | PPARA | Q07869 | 7/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL11606959 | 0.86 | LMNA (0.42) | LMNATSHRNFKB1PMP22HTT | |
| Sebacic Acid SCHEMBL11048318 | 0.85 | TSHR (0.44) | LMNATSHRNFKB1PMP22GAA | |
| Sebacic Acid SCHEMBL10624623 | 0.85 | TSHR (0.44) | LMNATSHRNFKB1PMP22GAA | |
| Sebacic Acid SCHEMBL3697622 | 0.85 | TSHR (0.44) | LMNATSHRNFKB1PMP22GAA | |
| Glutarate SCHEMBL11605405 | 0.82 | SLC22A6 (0.42) | LMNATSHRNFKB1PMP22HTT | |
| SCHEMBL15300050 | 0.82 | GAA (0.44) | LMNATSHRNFKB1PMP22GAA | |
| SCHEMBL11169821 | 0.82 | GAA (0.44) | LMNATSHRNFKB1PMP22GAA | |
| SCHEMBL15299972 | 0.82 | GAA (0.44) | LMNATSHRNFKB1PMP22GAA | |
| SCHEMBL4013079 | 0.82 | GAA (0.44) | LMNATSHRNFKB1PMP22GAA | |
| SCHEMBL15299849 | 0.82 | GAA (0.44) | LMNATSHRNFKB1PMP22GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2716678-B1 | SOLID PHASE POLYMERIZATION METHOD FOR PREPARING HIGH MOLECULAR WEIGHT ALIPHATIC POLYESTER | NATUREWORKS LLC (US) | 2018-04-25 | — | — | EP | disclosed |
| US-9290616-B2 | Solid-phase polymerization method for preparing high-molecular-weight aliphatic polyester | TORAY INDUSTRIES, INC. (JP) | 2016-03-22 | — | — | US | disclosed |
| US-20140100350-A1 | SOLID-PHASE POLYMERIZATION METHOD FOR PREPARING HIGH-MOLECULAR-WEIGHT ALIPHATIC POLYESTER | TORAY INDUSTRIES, INC. (JP) | 2014-04-10 | — | — | US | disclosed |