Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.45 |
| ▸ | KDM5C | P41229 | 7/20 | 0.45 |
| ▸ | KDM4A | O75164 | 6/20 | 0.45 |
| ▸ | KDM4B | O94953 | 2/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.39 |
| ▸ | KDM5A | P29375 | 8/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.38 |
| ▸ | KDM6B | O15054 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16297326 | 0.80 | KDM5B (0.43) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL16291866 | 0.69 | KDM5B (0.44) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL23120658 | 0.68 | KDM5B (0.52) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL15637115 | 0.68 | KDM5B (0.52) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL15637050 | 0.67 | KDM5B (0.42) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL17144427 | 0.67 | KDM5B (0.47) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL15635924 | 0.67 | KDM5B (0.45) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL15635926 | 0.67 | KDM5B (0.45) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL17772490 | 0.66 | KDM5B (0.50) | KDM5BKDM5CKDM4AKDM4BKDM4C | |
| SCHEMBL17144500 | 0.66 | KDM5B (0.61) | KDM5BKDM5CKDM4AKDM4BKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903968-A1 | INHIBITORS OF HISTONE DEMETHYLASES | Epitherapeutics ApS (DK) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014053491-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (DK) | 2014-04-10 | — | — | WO | disclosed |