Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.61 |
| ▸ | KDM4A | O75164 | 2/20 | 0.61 |
| ▸ | KDM5C | P41229 | 2/20 | 0.61 |
| ▸ | KDM4B | O94953 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | VNN1 | O95497 | 1/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL993562 | 0.83 | CYP1A2 (0.62) | CYP1A2CYP2D6ALDH1A1L3MBTL1VNN1 | |
| SCHEMBL20236126 | 0.80 | CYP1A2 (0.66) | CYP1A2CYP2D6ALDH1A1MAPK1USP2 | |
| SCHEMBL17145143 | 0.78 | KDM5B (0.53) | KDM5BKDM4AKDM5CKDM4BALDH1A1 | |
| SCHEMBL16925971 | 0.75 | KDM5B (0.51) | KDM5BKDM4AKDM5CKDM4BALDH1A1 | |
| SCHEMBL15637011 | 0.75 | KDM5B (0.77) | KDM5BKDM4AKDM5CKDM4BCYP1A2 | |
| SCHEMBL2861457 | 0.74 | CYP1A2 (1.00) | CYP1A2CYP2D6ALDH1A1MAPK1NPSR1 | |
| SCHEMBL17144440 | 0.74 | KDM5B (0.49) | KDM5BKDM4AKDM5CKDM4BKDM4C | |
| SCHEMBL8805346 | 0.74 | CYP1A2 (0.70) | CYP1A2CYP2D6ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL23120658 | 0.73 | KDM5B (0.52) | KDM5BKDM4AKDM5CKDM4BALDH1A1 | |
| SCHEMBL19779254 | 0.73 | VNN1 (0.77) | VNN1HDAC1HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170369444-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (DK) | 2017-12-28 | — | — | US | claimed |
| EP-3126345-A1 | INHIBITORS OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-02-08 | — | — | EP | claimed |
| WO-2015153498-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS, APS (DK) | 2015-10-08 | — | — | WO | claimed |
| US-20170369444-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (DK) | 2017-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369444-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM3A, KDM1A | KDM5B 33/4885KDM4A 20/4885KDM5C 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.