Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.63 |
| ▸ | KDM5C | P41229 | 8/20 | 0.63 |
| ▸ | KDM5A | P29375 | 7/20 | 0.63 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.63 |
| ▸ | KDM4A | O75164 | 2/20 | 0.58 |
| ▸ | KDM6B | O15054 | 1/20 | 0.58 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.58 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.57 |
| ▸ | THRA | P10827 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TLR2 | O60603 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636559 | 0.86 | KDM5B (0.66) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15636393 | 0.85 | KDM5B (0.67) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19565446 | 0.85 | KDM5B (0.64) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16291629 | 0.85 | KDM5B (0.64) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16912748 | 0.83 | KDM5B (0.71) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19676437 | 0.82 | KDM5B (0.61) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16925985 | 0.82 | KDM5B (0.61) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19676377 | 0.81 | KDM5B (0.63) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL18708527 | 0.81 | KDM5B (0.58) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15637682 | 0.79 | KDM5B (0.86) | KDM5BKDM5CKDM5AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903968-A1 | INHIBITORS OF HISTONE DEMETHYLASES | Epitherapeutics ApS (DK) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014053491-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (DK) | 2014-04-10 | — | — | WO | disclosed |