Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.71 |
| ▸ | KDM5C | P41229 | 8/20 | 0.71 |
| ▸ | KDM5A | P29375 | 8/20 | 0.71 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.71 |
| ▸ | KDM4A | O75164 | 2/20 | 0.61 |
| ▸ | KDM6B | O15054 | 1/20 | 0.61 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.61 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.60 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636393 | 0.87 | KDM5B (0.67) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15636559 | 0.87 | KDM5B (0.66) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16291629 | 0.85 | KDM5B (0.64) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19565446 | 0.85 | KDM5B (0.64) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16912747 | 0.85 | KDM5B (0.50) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19676437 | 0.84 | KDM5B (0.61) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19676377 | 0.84 | KDM5B (0.63) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15637431 | 0.84 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19676470 | 0.83 | KDM5B (0.86) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16925985 | 0.83 | KDM5B (0.61) | KDM5BKDM5CKDM5AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221139-B2 | Inhibitors of histone demethylases | GILEAD SCIENCES, INC. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20170320827-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2017-11-09 | — | — | US | disclosed |
| US-9611219-B2 | — | — | 2017-04-04 | — | — | US | disclosed |
| US-20150203453-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2015-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203453-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EHMT1, KDM1B, EHMT2 | KDM5B 34/4885KDM5C 31/4885KDM5A 25/4885 |
| US-20170320827-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EHMT1, KDM1B, EHMT2 | KDM5B 34/4885KDM5C 31/4885KDM5A 24/4885 |
| US-10221139-B2 | Inhibitors of histone demethylases | EHMT1, KDM1B, EHMT2 | KDM5B 34/4885KDM5C 31/4885KDM5A 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.