Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 11/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442966 | 1.00 | PIP4K2A (0.45) | PIP4K2APRMT5WDR77SLC22A12CDC7 | |
| SCHEMBL1442965 | 1.00 | PIP4K2A (0.45) | PIP4K2APRMT5WDR77SLC22A12CDC7 | |
| SCHEMBL16967987 | 0.92 | PIP4K2A (0.49) | PIP4K2APRMT5WDR77SLC22A12SRC | |
| SCHEMBL18571707 | 0.92 | ABL1 (0.44) | PIP4K2APRMT5WDR77SLC22A12CDC7 | |
| SCHEMBL16769947 | 0.87 | PRMT5 (0.44) | PIP4K2APRMT5WDR77SLC22A12NNMT | |
| SCHEMBL24753099 | 0.86 | PIP4K2A (0.44) | PIP4K2APRMT5WDR77SLC22A12SRC | |
| SCHEMBL1939828 | 0.86 | PIP4K2A (0.44) | PIP4K2APRMT5WDR77SLC22A12MAP4K4 | |
| SCHEMBL17877686 | 0.85 | PIP4K2A (0.44) | PIP4K2APRMT5WDR77SLC22A12MAP4K4 | |
| SCHEMBL1441891 | 0.85 | PIP4K2A (0.42) | PIP4K2APRMT5WDR77SLC22A12NNMT | |
| SCHEMBL9950030 | 0.85 | PIP4K2A (0.42) | PIP4K2APRMT5WDR77SLC22A12NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903989-A1 | PYRROLO[2,3-D]PYRIMIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS | Pfizer Limited (GB) | 2015-08-12 | — | — | EP | disclosed |
| US-20150218172-A1 | Pyrrolo[2,3-D]Pyrimidine Tropomyosin-Related Kinase Inhibitors | PFIZER LIMITED (GB) | 2015-08-06 | — | — | US | disclosed |
| US-20150218172-A1 | Pyrrolo[2,3-D]Pyrimidine Tropomyosin-Related Kinase Inhibitors | PFIZER LIMITED (GB) | 2015-08-06 | — | — | US | disclosed |
| US-20150218172-A1 | Pyrrolo[2,3-D]Pyrimidine Tropomyosin-Related Kinase Inhibitors | PFIZER LIMITED (GB) | 2015-08-06 | — | — | US | disclosed |
| WO-2014053967-A1 | PYRROLO[2,3-D]PYRIMIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER LIMITED (GB) | 2014-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218172-A1 | Pyrrolo[2,3-D]Pyrimidine Tropomyosin-Related Kinase Inhibitors | MUSK, DMPK, TPM3 | PIP4K2A 364/4885PRMT5 817/4885WDR77 2137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.