Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.94 |
| ▸ | CDK2AP1 | O14519 | 4/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563248 | 0.97 | CHEK1 (1.00) | CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL5394578 | 0.89 | CHEK1 (0.75) | CHEK1CDK2AP1 | |
| SCHEMBL4216725 | 0.89 | CHEK1 (0.75) | CHEK1CDK2AP1 | |
| SCHEMBL5554681 | 0.88 | CHEK1 (0.76) | CHEK1CDK2AP1MAP4K4 | |
| Hydrochloric Acid SCHEMBL4218123 | 0.88 | CHEK1 (0.74) | CHEK1CDK2AP1 | |
| SCHEMBL1564828 | 0.88 | CHEK1 (0.73) | CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL1563137 | 0.87 | CHEK1 (0.72) | CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL1563885 | 0.87 | CHEK1 (0.72) | CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL5394631 | 0.86 | CHEK1 (0.79) | CHEK1CDK2AP1 | |
| SCHEMBL4212966 | 0.86 | CHEK1 (0.79) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |