SCHEMBL156379

SCHEMBL156379

CNC(OP(=O)(OC(NC)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)n1[nH]c(CN2CCOC(O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2c2ccc(F)cc2)nc1=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 18/20 0.59
TACR3 P29371 2/20 0.59
NR3C1 P04150 1/20 0.59
CYP3A4 P08684 1/20 0.59
FPR1 P21462 1/20 0.59
GPR183 P32249 1/20 0.59
OPRD1 P41143 1/20 0.59
GPR65 Q8IYL9 1/20 0.59
GPR35 Q9HC97 1/20 0.59
TACR2 P21452 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22076806 1.00 TACR1 (0.59) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL21391935 0.95 TACR1 (0.57) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL20473749 0.91 TACR1 (0.60) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL1901932 0.89 TACR1 (0.48) TACR1TACR3NR3C1CYP3A4FPR1
Fosaprepitant SCHEMBL22076807 0.89 TACR1 (0.59) TACR1TACR3NR3C1CYP3A4FPR1
Fosaprepitant SCHEMBL17837327 0.89 TACR1 (0.59) TACR1TACR3NR3C1CYP3A4FPR1
Fosaprepitant SCHEMBL30861885 0.89 TACR1 (0.59) TACR1TACR3NR3C1CYP3A4FPR1
Fosaprepitant SCHEMBL156378 0.89 TACR1 (0.59) TACR1TACR3NR3C1CYP3A4FPR1
SCHEMBL1932400 0.88 TACR1 (0.57) TACR1TACR3NR3C1CYP3A4FPR1
Fosaprepitant SCHEMBL21955651 0.85 TACR1 (0.71) TACR1TACR3NR3C1CYP3A4FPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120088743-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS GRAS ESCARDO JORDI (ES) 2012-04-12 US disclosed
US-20120071452-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND CORTICOSTERIODS GRAS ESCARDO JORDI (ES) 2012-03-22 US disclosed
US-20120059031-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS GRAS ESCARDO JORDI (ES) 2012-03-08 US disclosed
US-20120040943-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS GRAS ESCARDO JORDI (ES) 2012-02-16 US disclosed
US-20110224177-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND CORTICOSTEROIDS GRAS ESCARDO JORDI 2011-09-15 US disclosed
WO-2011057757-A1 NEW 7-PHENYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE DERIVATIVES ALMIRALL, S.A. (ES) 2011-05-19 WO disclosed
EP-2319538-A2 Combinations combrising antimuscarinic agents and corticosteroids Almirall S.A. (ES) 2011-05-11 EP disclosed
EP-2292267-A2 Combinations comprising antimuscarinic agents and beta-adrenergic agonists Almirall S.A. (ES) 2011-03-09 EP disclosed
US-20110053936-A1 SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS ALMIRALL, S.A. (ES) 2011-03-03 US disclosed
US-20110046097-A1 SUBSTITUTED INDOLIN-2-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS ALMIRALL, S.A. (ES) 2011-02-24 US disclosed
US-20110021476-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS ESCARDO JORDI GRAS 2011-01-27 US disclosed
US-20110021477-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND CORTICOSTERIODS GRAS ESCARDO JORDI 2011-01-27 US disclosed
US-20110021478-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS GRAS ESCARDO JORDI 2011-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110021476-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS CHRM3, CHRM4, PDE4A TACR1 121/4885TACR3 125/4885NR3C1 1509/4885
US-20110021477-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND CORTICOSTERIODS CHRM3, CHRM2, NR3C2 TACR1 90/4885TACR3 213/4885NR3C1 11/4885
US-20120071452-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND CORTICOSTERIODS CHRM3, CHRM2, NR3C2 TACR1 90/4885TACR3 213/4885NR3C1 11/4885
US-20110046097-A1 SUBSTITUTED INDOLIN-2-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS MAPK1, MAPKAPK2, MAPK7 TACR1 3781/4885TACR3 4517/4885NR3C1 1228/4885
US-20120040943-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS ADRB2, ADRB3, CHRM3 TACR1 72/4885TACR3 117/4885NR3C1 282/4885
US-20110021478-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS CHRM3, PDE4A, CHRM4 TACR1 141/4885TACR3 213/4885NR3C1 591/4885
US-20110053936-A1 SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS MAPK1, MAP3K1, MAP3K7 TACR1 1430/4885TACR3 3342/4885NR3C1 565/4885
US-20120059031-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS CHRM3, CHRM4, PDE4A TACR1 121/4885TACR3 125/4885NR3C1 1509/4885
US-20110224177-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND CORTICOSTEROIDS CHRM3, CHRM2, CHRM5 TACR1 65/4885TACR3 103/4885NR3C1 34/4885
US-20120088743-A1 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS CHRM3, PDE4A, CHRM4 TACR1 159/4885TACR3 207/4885NR3C1 579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.