Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.31 |
| ▸ | FABP4 | P15090 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996109 | 0.83 | ALDH1A1 (0.54) | TYK2CCR4L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL23367842 | 0.79 | TYK2 (0.56) | TYK2CCR4APLNRCYP1A2CYP2D6 | |
| SCHEMBL15640894 | 0.77 | PDE10A (0.47) | L3MBTL1ALDH1A1TDP1CYP2C9LMNA | |
| SCHEMBL577982 | 0.75 | CCR4 (0.33) | TYK2CCR4SHMT1SHMT2PANK3 | |
| SCHEMBL2739326 | 0.74 | GFER (0.53) | ALDH1A1CYP19A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL62767 | 0.73 | SREBF2 (0.50) | CCR4L3MBTL1ALDH1A1CYP19A1LMNA | |
| SCHEMBL12869429 | 0.70 | KDM4E (0.58) | L3MBTL1ALDH1A1TDP1CYP19A1CYP1A2 | |
| SCHEMBL2116011 | 0.70 | IDH1 (0.33) | TYK2CCR4SHMT1SHMT2 | |
| SCHEMBL6224135 | 0.70 | ALDH1A1 (0.45) | TYK2CCR4L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL13996110 | 0.70 | ABL1 (0.43) | TYK2SHMT1SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697708-B2 | Azabenzothiazole compounds, compositions and methods of use | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-15 | — | — | US | disclosed |