Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903549 | 0.79 | MEN1 (0.40) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL22164450 | 0.78 | HDAC6 (0.34) | HDAC1HDAC2HDAC6 | |
| SCHEMBL10593995 | 0.77 | GABRR1 (0.35) | HDAC1HDAC2HDAC6 | |
| SCHEMBL10594008 | 0.77 | GABRR1 (0.35) | HDAC1HDAC2HDAC6 | |
| SCHEMBL7398555 | 0.76 | HMGCR (0.40) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL15156589 | 0.76 | HMGCR (0.40) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL7395136 | 0.73 | HDAC6 (0.33) | HDAC1HDAC2HDAC6 | |
| SCHEMBL30631300 | 0.73 | AAK1 (0.33) | HDAC1HDAC2HDAC6 | |
| SCHEMBL30631301 | 0.73 | AAK1 (0.33) | HDAC1HDAC2HDAC6 | |
| SCHEMBL30475222 | 0.73 | NAALAD2 (0.41) | MEN1KMT2AHDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697685-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-04-15 | — | — | US | disclosed |