Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398042 | 0.85 | L3MBTL1 (0.33) | HDAC6HDAC1HDAC2 | |
| SCHEMBL22164450 | 0.80 | HDAC6 (0.34) | HDAC6HDAC1HDAC2 | |
| SCHEMBL7398555 | 0.79 | HMGCR (0.40) | HDAC6HDAC1HDAC2 | |
| SCHEMBL15156589 | 0.79 | HMGCR (0.40) | HDAC6HDAC1HDAC2 | |
| SCHEMBL30475222 | 0.76 | NAALAD2 (0.41) | HDAC6HDAC1HDAC2 | |
| SCHEMBL28846132 | 0.76 | NAALAD2 (0.41) | HDAC6HDAC1HDAC2 | |
| SCHEMBL15640903 | 0.73 | MEN1 (0.31) | HDAC6HDAC1HDAC2 | |
| SCHEMBL186289 | 0.71 | HDAC6 (0.34) | HDAC6HDAC1HDAC2 | |
| SCHEMBL25182230 | 0.71 | L3MBTL1 (0.42) | HDAC1HDAC2 | |
| SCHEMBL31522777 | 0.71 | L3MBTL1 (0.42) | HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183238-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069816-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-23 | — | — | WO | disclosed |