Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 2/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | CPN1 | P15169 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16763687 | 1.00 | SLC6A1 (0.38) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL16763685 | 1.00 | SLC6A1 (0.38) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL612826 | 0.95 | SLC6A1 (0.43) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL124776 | 0.95 | SLC6A1 (0.43) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL14632099 | 0.95 | SLC6A1 (0.43) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL13719286 | 0.95 | SLC6A1 (0.43) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL476847 | 0.88 | SLC6A4 (0.37) | SLC6A1SLC6A11SLC6A13SLC6A2SLC6A4 | |
| SCHEMBL1290220 | 0.88 | SLC6A4 (0.37) | SLC6A1SLC6A11SLC6A13SLC6A2SLC6A4 | |
| SCHEMBL743575 | 0.88 | SLC6A4 (0.37) | SLC6A1SLC6A11SLC6A13SLC6A2SLC6A4 | |
| SCHEMBL28715568 | 0.80 | KDM4E (0.44) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |