Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602099 | 0.90 | DGAT1 (0.74) | DGAT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL602100 | 0.90 | DGAT1 (0.74) | DGAT1MEN1KMT2ANPC1RAB9A | |
| Bicarbonate SCHEMBL15653364 | 0.89 | DGAT1 (0.60) | DGAT1MEN1KMT2ANPC1RAB9A | |
| Bicarbonate SCHEMBL15656218 | 0.85 | DGAT1 (0.80) | DGAT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3669423 | 0.84 | DGAT1 (0.82) | DGAT1MEN1KMT2ANPC1RAB9A | |
| Bicarbonate SCHEMBL15654282 | 0.82 | DGAT1 (0.82) | DGAT1MEN1KMT2ANPC1RAB9A | |
| Bicarbonate SCHEMBL15654722 | 0.80 | DGAT1 (0.82) | DGAT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL602854 | 0.80 | DGAT1 (0.74) | DGAT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL602855 | 0.80 | DGAT1 (0.74) | DGAT1MEN1KMT2ANPC1RAB9A | |
| Bicarbonate SCHEMBL15655199 | 0.78 | DGAT1 (0.76) | DGAT1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-B1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-04-30 | — | — | EP | claimed |