Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.82 |
| ▸ | JAK1 | P23458 | 12/20 | 0.73 |
| ▸ | TYK2 | P29597 | 3/20 | 0.58 |
| ▸ | JAK3 | P52333 | 3/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.57 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | MERTK | Q12866 | 1/20 | 0.57 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.57 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.57 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL15653730 | 0.95 | JAK1 (0.80) | JAK2JAK1TYK2JAK3STK10 | |
| Cyclopropane SCHEMBL15653666 | 0.95 | JAK1 (0.80) | JAK2JAK1TYK2JAK3STK10 | |
| SCHEMBL2240163 | 0.90 | JAK2 (1.00) | JAK2JAK1TYK2JAK3STK10 | |
| Cyclopropane SCHEMBL15654993 | 0.90 | JAK2 (0.67) | JAK2JAK1TYK2JAK3STK10 | |
| Cyclopropane SCHEMBL15654463 | 0.90 | JAK2 (0.79) | JAK2JAK1TYK2JAK3STK10 | |
| Cyclopropane SCHEMBL15654018 | 0.88 | JAK2 (0.78) | JAK2JAK1TYK2JAK3STK10 | |
| Cyclopropane SCHEMBL15653691 | 0.86 | JAK2 (0.71) | JAK2JAK1TYK2JAK3STK10 | |
| Cyclopropane SCHEMBL15655025 | 0.85 | JAK2 (0.81) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2237089 | 0.84 | JAK1 (1.00) | JAK2JAK1TYK2JAK3STK10 | |
| Cyclopropane SCHEMBL15655137 | 0.84 | JAK2 (0.80) | JAK2JAK1TYK2JAK3STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361251-B1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2014-04-30 | — | — | EP | claimed |