Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.80 |
| ▸ | JAK1 | P23458 | 14/20 | 0.80 |
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | TYK2 | P29597 | 3/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | FLT4 | P35916 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | STAT1 | P42224 | 1/20 | 0.61 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | MERTK | Q12866 | 1/20 | 0.61 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.61 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.61 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL15654463 | 0.90 | JAK2 (0.79) | JAK2JAK1JAK3TYK2STK10 | |
| Cyclopropane SCHEMBL15653691 | 0.90 | JAK2 (0.71) | JAK2JAK1JAK3TYK2STK10 | |
| Cyclopropane SCHEMBL15654018 | 0.89 | JAK2 (0.78) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL2237575 | 0.89 | JAK1 (1.00) | JAK2JAK1JAK3TYK2STK10 | |
| Cyclopropane SCHEMBL15654113 | 0.87 | JAK3 (0.80) | JAK2JAK1JAK3TYK2STK10 | |
| Cyclopropane SCHEMBL15653757 | 0.87 | JAK2 (0.80) | JAK2JAK1JAK3TYK2STK10 | |
| Cyclopropane SCHEMBL15653080 | 0.87 | JAK1 (0.67) | JAK2JAK1JAK3TYK2STK10 | |
| Cyclopropane SCHEMBL15653666 | 0.87 | JAK1 (0.80) | JAK2JAK1JAK3TYK2STK10 | |
| Cyclopropane SCHEMBL15653730 | 0.87 | JAK1 (0.80) | JAK2JAK1JAK3TYK2STK10 | |
| Cyclopropane SCHEMBL15654799 | 0.86 | JAK2 (0.81) | JAK2JAK1JAK3TYK2STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361251-B1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2014-04-30 | — | — | EP | claimed |
| US-20100291151-A1 | 1-METHYLPYRAZOLE MODULATORS OF SUBSTANCE P, CALCITONIN GENE-RELATED PEPTIDE, ADRENERGIC RECEPTOR, AND/OR 5-HT RECEPTOR | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100291151-A1 | 1-METHYLPYRAZOLE MODULATORS OF SUBSTANCE P, CALCITONIN GENE-RELATED PEPTIDE, ADRENERGIC RECEPTOR, AND/OR 5-HT RECEPTOR | TACR1, HTR3A, HTR3C | JAK2 2588/4885JAK1 2767/4885JAK3 2390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.