Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15664078 | 0.89 | GRM5 (0.43) | GRM5PIK3CGMAPK1HSD17B10PDE10A | |
| SCHEMBL15663528 | 0.88 | GRM5 (0.48) | GRM5PIK3CGMAPK1POLBTSHR | |
| Hydrochloric Acid SCHEMBL17685486 | 0.79 | GRM5 (0.47) | GRM5PIK3CGMAPK1POLBTSHR | |
| SCHEMBL15664037 | 0.79 | PDE10A (0.45) | HSD17B10PDE10ANPC1RAB9A | |
| SCHEMBL2832741 | 0.79 | GRM5 (0.44) | GRM5PIK3CGMAPK1HSD17B10KMT2A | |
| SCHEMBL15663663 | 0.79 | PDE10A (0.45) | PDE10A | |
| SCHEMBL2824997 | 0.78 | GRM5 (0.48) | GRM5PIK3CGMAPK1POLBTSHR | |
| Hydrochloric Acid SCHEMBL17685494 | 0.78 | NPC1 (0.48) | GRM5PIK3CGMAPK1POLBTSHR | |
| SCHEMBL2827578 | 0.78 | GRM5 (0.50) | GRM5PIK3CGMAPK1POLBTSHR | |
| SCHEMBL15663639 | 0.78 | GRM5 (0.44) | GRM5PIK3CGMAPK1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858854-B1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2014-05-07 | — | — | EP | claimed |