Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828877 | 0.88 | RAB9A (0.52) | NPC1RAB9AKDM4EGAAMAPK1 | |
| SCHEMBL2827578 | 0.87 | GRM5 (0.50) | GRM5NPC1RAB9AKDM4EGAA | |
| Hydrochloric Acid SCHEMBL17685494 | 0.86 | NPC1 (0.48) | GRM5NPC1RAB9AKDM4EGAA | |
| Hydrochloric Acid SCHEMBL17685486 | 0.85 | GRM5 (0.47) | GRM5NPC1RAB9AKDM4EGAA | |
| SCHEMBL15663528 | 0.84 | GRM5 (0.48) | GRM5NPC1RAB9AKDM4EGAA | |
| SCHEMBL2829262 | 0.84 | GRM5 (0.44) | GRM5KDM4EPIK3CGNAMPTMAPT | |
| SCHEMBL2825843 | 0.84 | GRM5 (0.58) | GRM5NPC1RAB9ANAMPTSMN1; SMN2 | |
| SCHEMBL2831112 | 0.81 | IRAK4 (0.46) | GRM5GAANAMPTMAPK1MAPT | |
| SCHEMBL2830126 | 0.81 | NPC1 (0.42) | GRM5NPC1RAB9AMAPK1POLB | |
| SCHEMBL2827802 | 0.80 | SCD (0.48) | NPC1RAB9AKDM4EGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |