Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 6/20 | 0.65 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.65 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.65 |
| ▸ | P2RX4 | Q99571 | 5/20 | 0.62 |
| ▸ | P2RY1 | P47900 | 6/20 | 0.62 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | RNASEL | Q05823 | 3/20 | 0.60 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.59 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.59 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.59 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.59 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31552876 | 1.00 | P2RX3 (0.65) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL31552882 | 1.00 | P2RX3 (0.65) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL843429 | 0.92 | P2RY1 (0.64) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL31552885 | 0.92 | P2RY1 (0.64) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL18561528 | 0.90 | P2RX3 (0.67) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL19535617 | 0.90 | P2RX3 (0.67) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL601708 | 0.90 | P2RX3 (0.67) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL21008117 | 0.90 | P2RX3 (0.67) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL21007872 | 0.90 | P2RX3 (0.67) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL14853798 | 0.90 | P2RX3 (0.67) | P2RX3P2RX1P2RX2P2RX4P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150376581-A1 | T7 RNA POLYMERASE VARIANTS AND METHODS OF USING THE SAME | TECHNISCHE UNIVERSITAET DORTMUND (DE) | 2015-12-31 | — | — | US | claimed |
| EP-2912180-A1 | T7 RNA POLYMERASE VARIANTS AND METHODS OF USING THE SAME | Technische Universität Dortmund (DE) | 2015-09-02 | — | — | EP | claimed |
| WO-2014067551-A1 | T7 RNA POLYMERASE VARIANTS AND METHODS OF USING THE SAME | TECHNISCHE UNIVERSITÄT DORTMUND (DE) | 2014-05-08 | — | — | WO | claimed |
| US-20220145295-A1 | ENZYMATIC RNA SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-05-12 | — | — | US | disclosed |
| EP-3864151-A2 | ENZYMATIC RNA SYNTHESIS | President and Fellows of Harvard College (US) | 2021-08-18 | — | — | EP | disclosed |
| US-20150376581-A1 | T7 RNA POLYMERASE VARIANTS AND METHODS OF USING THE SAME | TECHNISCHE UNIVERSITAET DORTMUND (DE) | 2015-12-31 | — | — | US | disclosed |
| EP-2912180-A1 | T7 RNA POLYMERASE VARIANTS AND METHODS OF USING THE SAME | Technische Universität Dortmund (DE) | 2015-09-02 | — | — | EP | disclosed |
| WO-2014067551-A1 | T7 RNA POLYMERASE VARIANTS AND METHODS OF USING THE SAME | TECHNISCHE UNIVERSITÄT DORTMUND (DE) | 2014-05-08 | — | — | WO | disclosed |