Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5348782 | 0.81 | ROCK1 (0.56) | EPHX2ROCK1MEN1KMT2ASIGMAR1 | |
| SCHEMBL30768879 | 0.78 | POLB (0.80) | EPHX2MEN1KMT2APOLBSIGMAR1 | |
| SCHEMBL1567509 | 0.76 | KMT2A (0.51) | EPHX2MEN1KMT2AHRH3 | |
| SCHEMBL13357664 | 0.74 | HRH3 (0.58) | ROCK1MEN1KMT2ASIGMAR1HRH3 | |
| SCHEMBL5837135 | 0.74 | ROCK1 (0.62) | ROCK1CYP3A4SMN1; SMN2CITJAK2 | |
| SCHEMBL13357529 | 0.73 | ROCK1 (0.64) | EPHX2ROCK1CYP3A4CITJAK2 | |
| SCHEMBL3196780 | 0.73 | ROCK1 (0.73) | EPHX2ROCK1CYP3A4CITJAK2 | |
| SCHEMBL4256223 | 0.72 | EPHX2 (1.00) | EPHX2AURKAAURKB | |
| SCHEMBL6543337 | 0.72 | POLB (0.58) | EPHX2MEN1KMT2APOLBSIGMAR1 | |
| SCHEMBL13865086 | 0.72 | HRH3 (0.58) | EPHX2MEN1KMT2AHRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307017-A1 | COMPOUNDS WHICH CAN BE USED FOR THE TREATMENT OF CANCERS | Cytomics Systems (FR) | 2011-04-13 | — | — | EP | disclosed |