Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 8/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15674690 | 0.87 | ERN1 (0.36) | ERN1AKR1C3AKR1C2SMN1; SMN2 | |
| SCHEMBL15675097 | 0.85 | PTPN5 (0.43) | ERN1AKR1C3AKR1C2TOP2AMAPT | |
| SCHEMBL15675073 | 0.84 | TRPV1 (0.40) | ERN1KIF11AKR1C2TRPV1 | |
| SCHEMBL13376109 | 0.84 | ERN1 (0.41) | ERN1BACE1 | |
| SCHEMBL15674653 | 0.83 | PIK3CA (0.42) | ERN1ALOX5APFEN1PIK3CA | |
| SCHEMBL15675356 | 0.83 | ERN1 (0.39) | ERN1AKR1C3AKR1C2 | |
| SCHEMBL15675543 | 0.83 | ERN1 (0.43) | ERN1KIF11 | |
| SCHEMBL15675004 | 0.82 | ERN1 (0.40) | ERN1KIF11ALOX5APFEN1MAPT | |
| SCHEMBL15674648 | 0.82 | SLC22A12 (0.41) | ERN1AKR1C3AKR1C2 | |
| SCHEMBL15697798 | 0.82 | ERN1 (0.55) | ERN1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296696-B2 | Aryl derivatives and uses thereof | JACOBUS PHARMACEUTICALS COMPANY, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| EP-2917200-A1 | ARYL DERIVATIVES AND USES THEREOF | Jacobus Pharmaceutical Company, Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| US-20150080324-A1 | Aryl Derivatives And Uses Thereof | JACOBUS PHARMACEUTICAL COMPANY INC (US) | 2015-03-19 | — | — | US | disclosed |
| US-8962657-B2 | Aryl derivatives and uses thereof | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| WO-2014074778-A1 | ARYL DERIVATIVES AND USES THEREOF | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 2014-05-15 | — | — | WO | disclosed |
| US-20140135360-A1 | Aryl Derivatives And Uses Thereof | Jacobus Pharmaceutical Company, Inc (US) | 2014-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135360-A1 | Aryl Derivatives And Uses Thereof | G6PD, ABCC1, ABL1 | APP 2540/4885ERN1 2065/4885MAOA 782/4885 |
| US-20150080324-A1 | Aryl Derivatives And Uses Thereof | G6PD, ABCC1, ABL1 | APP 2540/4885ERN1 2065/4885MAOA 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.