Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | PNP | P00491 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15693168 | 0.85 | TNKS (0.55) | MAPTKDM4CHPGDALDH1A1KDM4E | |
| SCHEMBL15693149 | 0.82 | PARP1 (0.53) | MAPTKDM4CHPGDALDH1A1TSHR | |
| SCHEMBL15693151 | 0.75 | TNKS (0.47) | TNKSPARP1PARP15PARP14TNKS2 | |
| SCHEMBL15693148 | 0.75 | TNKS2 (0.58) | MAPTHPGDALDH1A1KDM4ETNKS | |
| SCHEMBL18712797 | 0.74 | PDE9A (0.68) | ALDH1A1KMT2A | |
| SCHEMBL15693145 | 0.74 | TNKS (0.46) | TNKSPARP1PARP15PARP14TNKS2 | |
| SCHEMBL15693144 | 0.74 | TNKS2 (0.56) | TNKSPARP1PARP15PARP14TNKS2 | |
| SCHEMBL15693146 | 0.74 | PARP1 (0.48) | KDM4CHPGDALDH1A1KDM4EKMT2A | |
| SCHEMBL20320595 | 0.73 | KDM4C (1.00) | MAPTKDM4CHPGDALDH1A1KDM4E | |
| SCHEMBL7280833 | 0.73 | HPGD (1.00) | MAPTKDM4CHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722661-B2 | Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase | HOFFMANN-LA ROCHE INC. (US) | 2014-05-13 | — | — | US | disclosed |
| US-8722661-B2 | Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase | HOFFMANN-LA ROCHE INC. (US) | 2014-05-13 | — | — | US | disclosed |