Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 15/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18712795 | 0.87 | PDE9A (0.63) | PDE9AMEN1KMT2A | |
| SCHEMBL16981642 | 0.85 | PDE9A (0.77) | PDE9A | |
| SCHEMBL16981668 | 0.81 | PDE9A (1.00) | PDE9A | |
| SCHEMBL16981734 | 0.78 | PDE9A (1.00) | PDE9A | |
| SCHEMBL16981692 | 0.76 | PDE9A (1.00) | PDE9A | |
| SCHEMBL26348826 | 0.76 | KDM4E (0.57) | PDE9AALDH1A1 | |
| SCHEMBL22119266 | 0.76 | PDE9A (0.58) | PDE9AALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL16981716 | 0.76 | PDE9A (1.00) | PDE9A | |
| SCHEMBL15693147 | 0.74 | MAPT (0.58) | ALDH1A1KMT2A | |
| SCHEMBL26010871 | 0.74 | PDE9A (0.38) | PDE9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617269-B2 | N-substituted pyrazolo [3,4-D] pyrimidine ketone compound, and preparation process and use thereof | SUN YAT-SEN UNIVERSITY (CN) | 2017-04-11 | — | — | US | disclosed |