Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.60 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.60 |
| ▸ | CCNC | P24863 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.60 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | CDK7 | P50613 | 1/20 | 0.60 |
| ▸ | CDK9 | P50750 | 1/20 | 0.60 |
| ▸ | CCNH | P51946 | 1/20 | 0.60 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18602089 | 0.91 | CDK8 (0.50) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL17106008 | 0.88 | CDK8 (0.50) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL18602159 | 0.87 | CDK8 (0.47) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL18602552 | 0.83 | CDK8 (0.41) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL17106013 | 0.82 | CDK8 (0.41) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL15699114 | 0.82 | CDK8 (0.41) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL18602299 | 0.81 | CDK8 (0.41) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL18602168 | 0.81 | CDK8 (0.41) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL15699107 | 0.79 | CDK8 (0.81) | CDK8CDK19CCNCCYP1A2CSNK2A2 | |
| SCHEMBL15699111 | 0.78 | CDK8 (0.79) | CDK8CDK19CCNCCYP1A2CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| EP-2917217-B1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA S A (PL) | 2017-03-08 | — | — | EP | disclosed |
| EP-2917217-B1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA S A (PL) | 2017-03-08 | — | — | EP | disclosed |
| US-20150274726-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA SA (PL) | 2015-10-01 | — | — | US | disclosed |
| US-20150274726-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA SA (PL) | 2015-10-01 | — | — | US | disclosed |
| WO-2014072435-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA SA (PL) | 2014-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274726-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | CDK8, CDK18, CDK9 | CDK8 1/4885CDK19 20/4885CCNC 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.