Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 10/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CASR | P41180 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15691868 | 0.94 | F11 (0.75) | F11ALDH1A1SMN1; SMN2LMNARECQL | |
| SCHEMBL18170346 | 0.93 | F11 (0.76) | F11ALDH1A1SMN1; SMN2LMNARECQL | |
| SCHEMBL15691852 | 0.93 | F11 (0.76) | F11ALDH1A1SMN1; SMN2LMNARECQL | |
| SCHEMBL15690601 | 0.88 | F11 (0.70) | F11ALDH1A1SMN1; SMN2LMNARECQL | |
| SCHEMBL18170347 | 0.88 | F11 (0.70) | F11ALDH1A1SMN1; SMN2LMNARECQL | |
| SCHEMBL15700029 | 0.85 | F11 (0.90) | F11 | |
| SCHEMBL15691862 | 0.85 | F11 (0.69) | F11ALDH1A1SMN1; SMN2LMNARECQL | |
| SCHEMBL18177865 | 0.84 | F11 (0.88) | F11 | |
| SCHEMBL18170355 | 0.83 | F11 (0.67) | F11ALDH1A1SMN1; SMN2LMNARECQL | |
| SCHEMBL18170353 | 0.83 | F11 (0.70) | F11ALDH1A1SMN1; SMN2LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758459-B2 | Allosteric modulators of factor XIa as anticoagulant agents | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-09-12 | — | — | US | disclosed |
| US-9758459-B2 | Allosteric modulators of factor XIa as anticoagulant agents | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160311842-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY | 2016-10-27 | — | — | US | disclosed |
| US-20160311842-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY | 2016-10-27 | — | — | US | disclosed |
| WO-2014075045-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2014-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311842-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | TFPI, TFPI2, F10 | F11 4/4885ALDH1A1 4470/4885SMN1; SMN2 4875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.