Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 8/20 | 0.31 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 4/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571094 | 1.00 | FGFR4 (0.32) | FGFR4GSK3BDYRK1ATYRO3MERTK | |
| SCHEMBL1571748 | 0.92 | DDR2 (0.33) | TYRO3MERTKDDR2MAP4K3MAP4K1 | |
| SCHEMBL1571351 | 0.86 | GSK3B (0.39) | GSK3BDYRK1ATYRO3MERTKDDR2 | |
| SCHEMBL1571670 | 0.84 | GSK3B (0.35) | GSK3BDYRK1ATYRO3MERTKDDR2 | |
| SCHEMBL1573257 | 0.84 | GSK3B (0.35) | GSK3BDYRK1ATYRO3MERTKDDR2 | |
| SCHEMBL1573258 | 0.84 | GSK3B (0.35) | GSK3BDYRK1ATYRO3MERTKDDR2 | |
| SCHEMBL1572814 | 0.82 | GSK3B (0.38) | GSK3BDYRK1ATYRO3MERTKDDR2 | |
| SCHEMBL1572812 | 0.82 | GSK3B (0.38) | GSK3BDYRK1ATYRO3MERTKDDR2 | |
| SCHEMBL1571672 | 0.82 | GSK3B (0.38) | GSK3BDYRK1ATYRO3MERTKDDR2 | |
| SCHEMBL1571675 | 0.81 | BRAF (0.36) | DDR2MAP4K3MAP4K1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307385-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |