Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 6/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.32 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | BLK | P51451 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571094 | 0.92 | FGFR4 (0.32) | DDR2MAP4K1MAP4K3BRAFCCNK | |
| SCHEMBL1571096 | 0.92 | FGFR4 (0.32) | DDR2MAP4K1MAP4K3BRAFCCNK | |
| SCHEMBL4423231 | 0.83 | MAP4K1 (0.38) | DDR2MAP4K1MAP4K3BRAFCCNA2 | |
| SCHEMBL1571675 | 0.83 | BRAF (0.36) | DDR2MAP4K1MAP4K3BRAF | |
| SCHEMBL1571982 | 0.82 | DDR2 (0.36) | DDR2MAP4K1MAP4K3BRAFTYRO3 | |
| SCHEMBL1571351 | 0.82 | GSK3B (0.39) | DDR2MAP4K1MAP4K3BRAFTYRO3 | |
| SCHEMBL1571762 | 0.82 | MAP4K1 (0.39) | MAP4K1MAP4K3BRAFCCNA2CDK2 | |
| SCHEMBL1571444 | 0.81 | SYK (0.38) | DDR2MAP4K1MAP4K3CCNA2CDK2 | |
| SCHEMBL1572647 | 0.81 | BRAF (0.41) | DDR2BRAFPIK3CA | |
| SCHEMBL1571606 | 0.80 | MAP4K1 (0.38) | MAP4K1MAP4K3BRAFCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307385-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |