SCHEMBL15712970

SCHEMBL15712970

Cc1ccc(C2=Cc3c(ccc(C)c3-c3ccccc3)C2[Si](C)(C)C2C(c3ccc(C)o3)=Cc3c2cc(C)c(C)c3-c2ccccc2)o1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.37
PTGS2 P35354 1/20 0.37
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
ALDH1A1 P00352 3/20 0.32
MAPT P10636 3/20 0.32
HPGD P15428 3/20 0.32
KDM4E B2RXH2 2/20 0.32
LMNA P02545 2/20 0.32
PKM P14618 2/20 0.32
GLA P06280 1/20 0.32
GAA P10253 1/20 0.32
ALOX15 P16050 1/20 0.32
CASP1 P29466 1/20 0.32
CASP7 P55210 1/20 0.32
HSD17B10 Q99714 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.30
ALOX12 P18054 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17066784 0.94 PTGS1 (0.40) PTGS1PTGS2ADORA2AADORA1MEN1
SCHEMBL2235899 0.92 PTGS1 (0.42) PTGS1PTGS2ADORA2AADORA1MEN1
SCHEMBL2234262 0.90 PTGS1 (0.40) PTGS1PTGS2ADORA2AADORA1MEN1
SCHEMBL18393704 0.83 PTGS1 (0.34) PTGS1PTGS2ADORA2AADORA1MEN1
Hydrochloric Acid SCHEMBL28329691 0.82 PTGS1 (0.34) PTGS1PTGS2ADORA2AADORA1MEN1
SCHEMBL2234850 0.82 KDM4E (0.31) MEN1KMT2AALDH1A1MAPTHPGD
SCHEMBL2233701 0.82 IKBKB (0.35) PTGS1PTGS2ADORA2AADORA1MEN1
SCHEMBL17060109 0.82 NPC1 (0.31) ALDH1A1NPC1RAB9A
SCHEMBL28677496 0.81 PTGS1 (0.33) PTGS1PTGS2ADORA2AADORA1
Hydrochloric Acid SCHEMBL28677533 0.81 PTGS1 (0.38) PTGS1PTGS2MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014069391-A1 METALLOCENE COMPLEX AND OLEFIN POLYMERIZATION METHOD 日本ポリプロ株式会社 (JP) 2014-05-08 WO disclosed