Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572814 | 0.91 | GSK3B (0.38) | MAP4K1 | |
| SCHEMBL1571672 | 0.91 | GSK3B (0.38) | MAP4K1 | |
| SCHEMBL1572812 | 0.91 | GSK3B (0.38) | MAP4K1 | |
| SCHEMBL1571982 | 0.82 | DDR2 (0.36) | BRAFMAP4K1 | |
| SCHEMBL1573257 | 0.80 | GSK3B (0.35) | BRAF | |
| SCHEMBL1573258 | 0.80 | GSK3B (0.35) | BRAF | |
| SCHEMBL1571351 | 0.79 | GSK3B (0.39) | BRAFMAP4K1 | |
| SCHEMBL13362831 | 0.79 | GSK3B (0.41) | BRAFMAP4K1 | |
| SCHEMBL1571237 | 0.79 | GSK3B (0.41) | BRAFMAP4K1 | |
| SCHEMBL1571239 | 0.79 | GSK3B (0.41) | BRAFMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307385-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |