Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 11/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | TTK | P33981 | 2/20 | 0.34 |
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572812 | 0.91 | GSK3B (0.38) | DDR2MAP4K3MAP4K1MAPK1TTK | |
| SCHEMBL1571672 | 0.91 | GSK3B (0.38) | DDR2MAP4K3MAP4K1MAPK1TTK | |
| SCHEMBL1572814 | 0.91 | GSK3B (0.38) | DDR2MAP4K3MAP4K1MAPK1TTK | |
| SCHEMBL1572755 | 0.88 | MAP4K1 (0.38) | MAP4K3MAP4K1TTKJUNMAPK8 | |
| SCHEMBL1571606 | 0.88 | MAP4K1 (0.38) | MAP4K3MAP4K1TTKJUNMAPK8 | |
| SCHEMBL4423231 | 0.88 | MAP4K1 (0.38) | DDR2MAP4K3MAP4K1MAPK1TTK | |
| SCHEMBL1571877 | 0.88 | MAP4K1 (0.38) | MAP4K3MAP4K1TTKJUNMAPK8 | |
| SCHEMBL1571511 | 0.86 | ACACB (0.40) | DDR2MAP4K3MAP4K1MAPK1BRAF | |
| SCHEMBL1571444 | 0.86 | SYK (0.38) | DDR2MAP4K3MAP4K1TTKJUN | |
| SCHEMBL1870122 | 0.85 | MAPK1 (0.35) | DDR2MAP4K3MAP4K1MAPK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307385-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |