Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 13/20 | 0.74 |
| ▸ | MYC | P01106 | 5/20 | 0.59 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15714398 | 0.81 | MYC (0.79) | NOTUMMYCNR4A1ALDH1A1POLB | |
| SCHEMBL15714569 | 0.81 | MYC (0.71) | NOTUMMYCNR4A1ALDH1A1POLB | |
| SCHEMBL15714567 | 0.80 | MAPT (0.54) | NOTUMMYCALDH1A1 | |
| SCHEMBL17172477 | 0.80 | NOTUM (0.79) | NOTUMMYCNR4A1ALDH1A1 | |
| SCHEMBL1380808 | 0.75 | NOTUM (0.69) | NOTUMALDH1A1 | |
| SCHEMBL14360567 | 0.75 | MYC (0.54) | NOTUMMYCNR4A1ALDH1A1POLB | |
| SCHEMBL17172422 | 0.75 | MYC (1.00) | NOTUMMYCNR4A1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL2025123 | 0.74 | NOTUM (0.68) | NOTUMALDH1A1 | |
| SCHEMBL17172440 | 0.74 | MYC (1.00) | NOTUMMYCNR4A1ALDH1A1POLB | |
| SCHEMBL17172439 | 0.73 | MYC (1.00) | NOTUMMYCNR4A1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917203-B1 | METHOD FOR IDENTIFYING MYC INHIBITORS | DANA FARBER CANCER INST INC (US) | 2019-04-03 | — | — | EP | disclosed |
| US-9567301-B2 | Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-02-14 | — | — | US | disclosed |
| US-9540320-B2 | — | — | 2017-01-10 | — | — | US | disclosed |
| US-20150291521-A1 | PYRROL-1-YL BENZOIC ACID DERIVATIVES USEFUL AS MYC INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. | 2015-10-15 | — | — | US | disclosed |
| WO-2014071247-A1 | PYRROL-1 -YL BENZOIC ACID DERIVATES USEFUL AS MYC INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291521-A1 | PYRROL-1-YL BENZOIC ACID DERIVATIVES USEFUL AS MYC INHIBITORS | MYC, MYCBP, YAP1 | NOTUM 2568/4885MYC 1/4885NR4A1 3212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.