YAP1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1310829	0.41	12/20
SCHEMBL1123233	0.51	10/20
SCHEMBL1310154	0.38	9/20
SCHEMBL1312855	0.38	9/20
SCHEMBL2154559	0.38	9/20
SCHEMBL1122808	0.51	8/20
SCHEMBL2165348	0.46	8/20
SCHEMBL2165354	0.46	8/20
SCHEMBL865572	0.57	7/20
SCHEMBL865573	0.57	7/20
SCHEMBL1123231	0.50	7/20
SCHEMBL1310689	0.38	7/20
SCHEMBL1313222	0.37	6/20
SCHEMBL2159537	0.36	6/20
SCHEMBL1887127	0.66	5/20
SCHEMBL1887157	0.58	5/20
SCHEMBL1878090	0.56	5/20
SCHEMBL1122645	0.54	5/20
SCHEMBL2154970	0.36	5/20
SCHEMBL1888843	0.59	4/20

Clinical trials — most relevant to YAP1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
SCARFREE-001: Verteporfin for Scar Prevention	PHASE2	NOT_YET_RECRUITING
Neoadjuvant Zoledronate and Atorvastatin in Triple Negative Breast Cancer	PHASE2	COMPLETED
T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer	PHASE2	RECRUITING
Targeting the Hippo Transducer TAZ in Breast Cancer With Statins	PHASE2	UNKNOWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Trial of Dasatinib (Sprycel®) in Subjects With Hormone-refractory Prostate Cancer	PHASE2	COMPLETED
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Itacitinib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Epithelioid Haemangioendothelioma Observational Study	nan	RECRUITING
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis	nan	COMPLETED
The Activation of Hippo Pathway in Nasal Polyps	nan	UNKNOWN
Hippo-Related Competing Endogenous RNA (ceRNA) Network Dysregulation and In Vitro Fertilization (IVF) Outcomes in Women With Diminished Ovarian Reserve	nan	NOT_YET_RECRUITING
IVM for Patients With Low Ovarian Response. Does it Improve IVFoutcomes and Does it Improve the Following IVF Cycle?	nan	UNKNOWN
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer	nan	UNKNOWN
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study	nan	COMPLETED
Tissue Predictors of Abiraterone Benefit	nan	COMPLETED
Study of Proteins in Head and Neck Cancer Cells	nan	COMPLETED
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility	nan	RECRUITING
Integrated Molecular Profiling in Advanced Cancers Trial	nan	ACTIVE_NOT_RECRUITING
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Pediatric Solid Tumor Metabolism [A Prospective Study Exploring Metabolism of Solid Tumors in Pediatrics]	nan	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Identification and Validation of Noninvasive Biomarkers of the Diagnosis and Severity of NASH in Type 2 Diabetics	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Prostate Cancer Prevention Clinic for Men With Risk of Familial Prostate Cancer	nan	NOT_YET_RECRUITING
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases	nan	NOT_YET_RECRUITING
Genetic Susceptibility in MAlignant Pleural Mesothelioma: Clinical Implication of GermliNE variaTionS	nan	RECRUITING
Study for the Multidimensional Analyses of Resistance and Toxicity to Immune- and Targeted-therapies.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a YAP1 binder may also engage these)

Protein	Name	Similarity
A0A8C0NGY6	—	1.000	A0A8C0NGY6 →
Q2EJA0	—	1.000	Q2EJA0 →
Q1L8J7	—	1.000	Q1L8J7 →
D6C652	—	1.000	D6C652 →
H2LBU8	—	1.000	H2LBU8 →
Q9GZV5	—	1.000	Q9GZV5 →
P46936	—	1.000	P46936 →
A0A8I3PQN6	—	1.000	A0A8I3PQN6 →
Q58NQ4	—	1.000	Q58NQ4 →
Q32NJ6	—	0.999	Q32NJ6 →
P46938	—	0.999	P46938 →
Q9H334	—	0.999	Q9H334 →
P23899	—	0.998	P23899 →
Q9EPK5	—	0.998	Q9EPK5 →
Q99PM1	—	0.998	Q99PM1 →
Q4VYS1	—	0.997	Q4VYS1 →
Q4VYR7	—	0.997	Q4VYR7 →
TFEB	Transcription factor EB	0.997	landscape →
P40645	—	0.997	P40645 →
A2BEA6	—	0.997	A2BEA6 →
P41846	—	0.997	P41846 →
Q28EM1	—	0.996	Q28EM1 →
G5EFF5	—	0.996	G5EFF5 →
Q0P5K4	—	0.996	Q0P5K4 →
Q80TZ9	—	0.996	Q80TZ9 →
Q8MJ98	—	0.996	Q8MJ98 →
Q5QL03	—	0.996	Q5QL03 →
P0CF24	—	0.996	P0CF24 →
Q498D1	—	0.996	Q498D1 →
P27889	—	0.996	P27889 →