Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30449036 | 1.00 | ALDH1A1 (0.42) | ALDH1A1CYP1A2OPRM1DDB1CRBN | |
| SCHEMBL250230 | 1.00 | ALDH1A1 (0.42) | ALDH1A1CYP1A2OPRM1DDB1CRBN | |
| SCHEMBL13735685 | 0.95 | ALDH1A1 (0.44) | ALDH1A1CYP1A2OPRM1DDB1CRBN | |
| SCHEMBL13735691 | 0.95 | ALDH1A1 (0.44) | ALDH1A1CYP1A2OPRM1DDB1CRBN | |
| SCHEMBL7744577 | 0.91 | ALDH1A1 (0.44) | ALDH1A1CYP1A2OPRM1DDB1CRBN | |
| SCHEMBL12196085 | 0.89 | ALDH1A1 (0.42) | ALDH1A1CYP1A2OPRM1DDB1CRBN | |
| SCHEMBL28446534 | 0.83 | CYP1A2 (0.32) | ALDH1A1CYP1A2OPRM1DDB1CRBN | |
| SCHEMBL12195995 | 0.79 | ALDH1A1 (0.47) | ALDH1A1CYP1A2OPRM1HPGDAPOBEC3G | |
| SCHEMBL17080079 | 0.78 | TTR (0.41) | ALDH1A1OPRM1CHRM2HPGDMAPT | |
| SCHEMBL8891392 | 0.74 | ALDH1A1 (0.41) | ALDH1A1CYP1A2OPRM1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307376-B1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-11-04 | — | — | EP | disclosed |
| EP-2307376-B1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-11-04 | — | — | EP | disclosed |
| US-8889719-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889719-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889719-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| EP-2307376-A1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | Merck Patent GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010017051-A1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | MERCK SERONO S.A. (CH) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010017051-A1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | MERCK SERONO S.A. (CH) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MKI67, FGFR1, IGF1R | ALDH1A1 406/4885CYP1A2 2644/4885OPRM1 3072/4885 |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MKI67, FGFR1, IGF1R | ALDH1A1 406/4885CYP1A2 2644/4885OPRM1 3072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.