Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27077302 | 1.00 | MAPK1 (0.44) | MAPK1SMN1; SMN2NPSR1HPGDHDAC4 | |
| SCHEMBL17846383 | 0.87 | MAPK1 (0.41) | MAPK1SMN1; SMN2NPSR1HPGDHDAC4 | |
| SCHEMBL27077289 | 0.85 | KDM1A (0.39) | SMN1; SMN2HPGDKDM1AMAOBMAOA | |
| SCHEMBL22032451 | 0.84 | KDM1A (0.40) | SMN1; SMN2NPSR1HPGDKDM1AMAOB | |
| SCHEMBL22032415 | 0.84 | KDM1A (0.40) | SMN1; SMN2NPSR1HPGDKDM1AMAOB | |
| SCHEMBL16401194 | 0.84 | KDM1A (0.40) | SMN1; SMN2NPSR1HPGDKDM1AMAOB | |
| SCHEMBL25053381 | 0.80 | KDM1A (0.56) | MAPK1KDM1AMAOB | |
| SCHEMBL18723453 | 0.73 | KCNH2 (0.39) | SMN1; SMN2HPGDKDM1AMAOB | |
| SCHEMBL18723693 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2NPSR1KDM1AMAOBMAOA | |
| SCHEMBL8085859 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2NPSR1HPGDKDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014078372-A1 | PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |