Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16401194 | 0.88 | KDM1A (0.40) | SMN1; SMN2NPSR1KDM1AHPGDCISD1 | |
| SCHEMBL22032415 | 0.88 | KDM1A (0.40) | SMN1; SMN2NPSR1KDM1AHPGDCISD1 | |
| SCHEMBL22032451 | 0.88 | KDM1A (0.40) | SMN1; SMN2NPSR1KDM1AHPGDCISD1 | |
| SCHEMBL25619917 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2ATMALDH1A1HPGDKDM4E | |
| SCHEMBL25053373 | 0.81 | KDM1A (0.57) | KDM1AMAOB | |
| SCHEMBL22086333 | 0.81 | KDM1A (0.57) | KDM1AMAOB | |
| SCHEMBL29116029 | 0.81 | KDM1A (0.57) | KDM1AMAOB | |
| SCHEMBL29373513 | 0.81 | KDM1A (0.57) | KDM1AMAOB | |
| SCHEMBL30141966 | 0.80 | KDM1A (0.45) | KDM1ACISD1SLC6A2MAOBHTR1B | |
| SCHEMBL16403103 | 0.80 | KDM1A (0.45) | KDM1ACISD1SLC6A2MAOBHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |