Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301182 | 0.87 | LMNA (0.55) | LMNAALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL1386528 | 0.83 | LMNA (0.57) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL967320 | 0.80 | LMNA (0.70) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27708825 | 0.79 | LMNA (0.68) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3920435 | 0.77 | LMNA (0.56) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27620333 | 0.77 | KDM4E (0.54) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1416041 | 0.77 | LMNA (0.50) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| Decane SCHEMBL9298496 | 0.76 | LMNA (0.54) | LMNAALDH1A1TSHRCA12 | |
| Hexadecane SCHEMBL9298501 | 0.76 | LMNA (0.54) | LMNAALDH1A1TSHRCA12 | |
| SCHEMBL17936653 | 0.75 | LMNA (0.43) | LMNAALDH1A1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014078331-A1 | N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |