Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 4/20 | 0.40 |
| ▸ | AKT2 | P31751 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13736647 | 0.78 | RECQL (0.51) | PTGER1KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13739831 | 0.74 | ALDH1A1 (0.55) | LMNASMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL18864266 | 0.73 | MEN1 (0.53) | PTGER1KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13738541 | 0.72 | TDP1 (0.51) | KDM4ELMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL13736982 | 0.70 | RECQL (0.44) | PTGER1KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13738455 | 0.70 | MAPT (0.45) | LMNASMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL15661063 | 0.70 | PTGIR (0.42) | PTGER1KDM4ELMNAALDH1A1PKM | |
| SCHEMBL6266547 | 0.69 | PTGER1 (0.47) | PTGER1KDM4ESMN1; SMN2ALDH1A1GAA | |
| SCHEMBL15657185 | 0.69 | NR1H2 (0.41) | PTGER1KDM4ELMNAALDH1A1PKM | |
| SCHEMBL13739586 | 0.68 | PTGER1 (0.38) | PTGER1KDM4ELMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014078331-A1 | N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |