Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14533958 | 1.00 | HTT (0.36) | HTTCETP | |
| SCHEMBL14533959 | 1.00 | HTT (0.36) | HTTCETP | |
| SCHEMBL5463080 | 0.80 | CA1 (0.31) | — | |
| SCHEMBL3990465 | 0.76 | CA1 (0.34) | HTT | |
| SCHEMBL11874172 | 0.76 | — | — | |
| SCHEMBL1623537 | 0.76 | OR51E2 (0.46) | HTT | |
| SCHEMBL3917158 | 0.76 | HTT (0.32) | HTT | |
| SCHEMBL29199307 | 0.74 | OR51E2 (0.43) | HTT | |
| SCHEMBL2714639 | 0.74 | NOS2 (0.33) | HTT | |
| SCHEMBL30366215 | 0.74 | CA1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3397629-B1 | METALLOENZYME INHIBITOR COMPOUNDS | NQP 1598 LTD (KY) | 2023-04-19 | — | — | EP | claimed |
| EP-3397629-B1 | METALLOENZYME INHIBITOR COMPOUNDS | NQP 1598 LTD (KY) | 2023-04-19 | — | — | EP | disclosed |
| CN-108524533-A | A kind of compound is used as antitumor drug synergist and reversal agent | 中国科学院动物研究所 | 2018-09-14 | — | — | CN | disclosed |
| EP-2919782-B1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-04-26 | — | — | EP | disclosed |
| EP-2919782-B1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-04-26 | — | — | EP | disclosed |
| US-9428492-B2 | Secondary alcohol substituted triazoles as PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-9428492-B2 | Secondary alcohol substituted triazoles as PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-20150284368-A1 | SECONDARY ALCOHOL SUBSTITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-08 | — | — | US | disclosed |
| US-20150284368-A1 | SECONDARY ALCOHOL SUBSTITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-08 | — | — | US | disclosed |
| EP-2919782-A1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014078220-A1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-05-22 | — | — | WO | disclosed |
| WO-2014078220-A1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284368-A1 | SECONDARY ALCOHOL SUBSTITUTED TRIAZOLES AS PDE10 INHIBITORS | PDE10A, PDE3A, PDE4B | HTT 106/4885CETP 3083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.