SCHEMBL1571817

SCHEMBL1571817

FC(F)(F)c1cn[c][nH]1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2096324 0.65 IKBKB (0.36)
SCHEMBL4411541 0.64 KDM4E (0.34)
SCHEMBL569598 0.60
SCHEMBL1424384 0.60
SCHEMBL1529258 0.56
Hydrochloric Acid SCHEMBL22188751 0.54 MASP2 (0.38)
SCHEMBL20589156 0.54 MASP2 (0.38)
SCHEMBL9902177 0.51
Trifluoromethylbenzene SCHEMBL23087097 0.46
SCHEMBL21306240 0.41 KDM4E (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2011524881-A 2011-09-08 JP claimed
EP-2307385-A1 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES Novartis AG (CH) 2011-04-13 EP claimed
US-20100311748-A1 HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS ASTRAZENECA AB (SE) 2010-12-09 US claimed
EP-2188255-A1 HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS AstraZeneca AB (SE) 2010-05-26 EP claimed
US-20100121052-A1 Novel compounds for treating proliferative diseases JAIN RAMA 2010-05-13 US claimed
WO-2009153313-A1 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES NOVARTIS AG (CH) 2009-12-23 WO claimed
WO-2009027746-A1 HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS ASTRAZENECA AB (SE) 2009-03-05 WO claimed
EP-1333834-A4 ANTIINFLAMMATION AGENTS AMGEN INC (US) 2007-01-17 EP claimed
EP-1444223-A1 AMINOPYRIMIDINES AND -PYRIDINES F. HOFFMANN-LA ROCHE AG (CH) 2004-08-11 EP claimed
EP-1333834-A2 ANTIINFLAMMATION AGENTS Tularik Inc. (US) 2003-08-13 EP claimed
WO-2003048152-A2 INFLAMMATION MODULATORS TULARIK INC. (US) 2003-06-12 WO claimed
WO-2003040131-A1 AMINOPYRIMIDINES AND PYRIDINES F. HOFFMANN-LA ROCHE AG (CH) 2003-05-15 WO claimed
WO-2002041843-A2 ANTIINFLAMMATION AGENTS TULARIK INC. (US) 2002-05-30 WO claimed
EP-2597088-B1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO (JP) 2017-11-01 EP disclosed
EP-2631229-B1 P2X4 RECEPTOR ANTAGONIST NIPPON CHEMIPHAR CO (JP) 2014-12-03 EP disclosed
US-8673915-B2 P 2×4 receptor antagonist NIPPON CHEMIPHAR CO., LTD. (JP) 2014-03-18 US disclosed
WO-2002041843-A2 ANTIINFLAMMATION AGENTS TULARIK INC. (US) 2002-05-30 WO disclosed
EP-0126581-B1 ANTIFUNGAL TRIAZOLE DERIVATIVES Pfizer Limited (GB) 1987-06-03 EP disclosed
US-4554286-A Antifungal 1-triazolyl-2-aryl-3-(5-trifluoromethylimidazol-1-yl)propan-2-ol derivatives PFIZER INC. (US) 1985-11-19 US disclosed
EP-0126581-A1 Antifungal triazole derivatives Pfizer Limited (GB) 1984-11-28 EP disclosed